Communications Biology (Oct 2022)
ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma
- Kavita Praveen,
- Gaurang C. Patel,
- Lauren Gurski,
- Ariane H. Ayer,
- Trikaladarshi Persaud,
- Matthew D. Still,
- Lawrence Miloscio,
- Tavé Van Zyl,
- Silvio Alessandro Di Gioia,
- Ben Brumpton,
- Kristi Krebs,
- Bjørn Olav Åsvold,
- Esteban Chen,
- Venkata R. M. Chavali,
- Wen Fury,
- Harini V. Gudiseva,
- Sarah Hyde,
- Eric Jorgenson,
- Stephanie Lefebvre,
- Dadong Li,
- Alexander Li,
- James Mclninch,
- Brijeshkumar Patel,
- Jeremy S. Rabinowitz,
- Rebecca Salowe,
- Claudia Schurmann,
- Anne-Sofie Seidelin,
- Eli Stahl,
- Dylan Sun,
- Tanya M. Teslovich,
- Anne Tybjærg-Hansen,
- Cristen Willer,
- Scott Waldron,
- Sabrina Walley,
- Hua Yang,
- Sarthak Zaveri,
- Regeneron Genetics Center,
- GHS-RGC DiscovEHR Collaboration,
- Estonian Biobank Research Team,
- Ying Hu,
- Kristian Hveem,
- Olle Melander,
- Lili Milani,
- Stefan Stender,
- Joan M. O’Brien,
- Marcus B. Jones,
- Gonçalo R. Abecasis,
- Michael N. Cantor,
- Jonathan Weyne,
- Katia Karalis,
- Aris Economides,
- Giusy Della Gatta,
- Manuel A. Ferreira,
- George D. Yancopoulos,
- Aris Baras,
- Carmelo Romano,
- Giovanni Coppola
Affiliations
- Kavita Praveen
- Regeneron Genetics Center
- Gaurang C. Patel
- Regeneron Pharmaceuticals, Inc.
- Lauren Gurski
- Regeneron Genetics Center
- Ariane H. Ayer
- Regeneron Genetics Center
- Trikaladarshi Persaud
- Regeneron Genetics Center
- Matthew D. Still
- Regeneron Pharmaceuticals, Inc.
- Lawrence Miloscio
- Regeneron Genetics Center
- Tavé Van Zyl
- Regeneron Pharmaceuticals, Inc.
- Silvio Alessandro Di Gioia
- Regeneron Genetics Center
- Ben Brumpton
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology
- Kristi Krebs
- Estonian Genome Centre, Institute of Genomics, University of Tartu
- Bjørn Olav Åsvold
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology
- Esteban Chen
- Regeneron Genetics Center
- Venkata R. M. Chavali
- Department of Ophthalmology, Pearlman School of Medicine, University of Pennsylvania
- Wen Fury
- Regeneron Pharmaceuticals, Inc.
- Harini V. Gudiseva
- Department of Ophthalmology, Pearlman School of Medicine, University of Pennsylvania
- Sarah Hyde
- Alnylam Pharmaceuticals, Inc
- Eric Jorgenson
- Regeneron Genetics Center
- Stephanie Lefebvre
- Alnylam Pharmaceuticals, Inc
- Dadong Li
- Regeneron Genetics Center
- Alexander Li
- Regeneron Genetics Center
- James Mclninch
- Alnylam Pharmaceuticals, Inc
- Brijeshkumar Patel
- Regeneron Pharmaceuticals, Inc.
- Jeremy S. Rabinowitz
- Regeneron Pharmaceuticals, Inc.
- Rebecca Salowe
- Department of Ophthalmology, Pearlman School of Medicine, University of Pennsylvania
- Claudia Schurmann
- Bayer AG, Pharmaceuticals, Research and Development
- Anne-Sofie Seidelin
- Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital
- Eli Stahl
- Regeneron Genetics Center
- Dylan Sun
- Regeneron Genetics Center
- Tanya M. Teslovich
- Regeneron Genetics Center
- Anne Tybjærg-Hansen
- Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital
- Cristen Willer
- Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan
- Scott Waldron
- Alnylam Pharmaceuticals, Inc
- Sabrina Walley
- Regeneron Pharmaceuticals, Inc.
- Hua Yang
- Regeneron Pharmaceuticals, Inc.
- Sarthak Zaveri
- Regeneron Pharmaceuticals, Inc.
- Regeneron Genetics Center
- GHS-RGC DiscovEHR Collaboration
- Estonian Biobank Research Team
- Ying Hu
- Regeneron Pharmaceuticals, Inc.
- Kristian Hveem
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology
- Olle Melander
- Lund University, Department of Clinical Sciences Malmö
- Lili Milani
- Estonian Genome Centre, Institute of Genomics, University of Tartu
- Stefan Stender
- Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital
- Joan M. O’Brien
- Department of Ophthalmology, Pearlman School of Medicine, University of Pennsylvania
- Marcus B. Jones
- Regeneron Genetics Center
- Gonçalo R. Abecasis
- Regeneron Genetics Center
- Michael N. Cantor
- Regeneron Genetics Center
- Jonathan Weyne
- Regeneron Pharmaceuticals, Inc.
- Katia Karalis
- Regeneron Genetics Center
- Aris Economides
- Regeneron Genetics Center
- Giusy Della Gatta
- Regeneron Genetics Center
- Manuel A. Ferreira
- Regeneron Genetics Center
- George D. Yancopoulos
- Regeneron Pharmaceuticals, Inc.
- Aris Baras
- Regeneron Genetics Center
- Carmelo Romano
- Regeneron Pharmaceuticals, Inc.
- Giovanni Coppola
- Regeneron Genetics Center
- DOI
- https://doi.org/10.1038/s42003-022-03932-6
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 15
Abstract
Rare variant association data from human genetics combined with in vitro and in vivo functional validation highlight ANGPTL7 as a promising therapeutic target for intraocular pressure reduction, and protection from glaucoma.
