Nature Communications (Oct 2018)

An ultra-low thiourea catalyzed strain-release glycosylation and a multicatalytic diversification strategy

  • Chunfa Xu,
  • Charles C. J. Loh

DOI
https://doi.org/10.1038/s41467-018-06329-4
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Non-covalent glycosyl donor activation often requires high organocatalyst loadings. Here, the authors demonstrate that strain-release glycosylations can take place at very low thiourea catalyst loadings. In addition, the authors developed a one-pot multicatalytic strategy that can diversify glycosides rapidly.