Nature Communications (Jun 2022)
T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles
- Pablo F. Céspedes,
- Ashwin Jainarayanan,
- Lola Fernández-Messina,
- Salvatore Valvo,
- David G. Saliba,
- Elke Kurz,
- Audun Kvalvaag,
- Lina Chen,
- Charity Ganskow,
- Huw Colin-York,
- Marco Fritzsche,
- Yanchun Peng,
- Tao Dong,
- Errin Johnson,
- Jesús A. Siller-Farfán,
- Omer Dushek,
- Erdinc Sezgin,
- Ben Peacock,
- Alice Law,
- Dimitri Aubert,
- Simon Engledow,
- Moustafa Attar,
- Svenja Hester,
- Roman Fischer,
- Francisco Sánchez-Madrid,
- Michael L. Dustin
Affiliations
- Pablo F. Céspedes
- Kennedy Institute of Rheumatology, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, The University of Oxford
- Ashwin Jainarayanan
- Kennedy Institute of Rheumatology, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, The University of Oxford
- Lola Fernández-Messina
- Immunology Service, Hospital de la Princesa, Instituto Investigación Sanitaria Princesa, Universidad Autónoma de Madrid
- Salvatore Valvo
- Kennedy Institute of Rheumatology, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, The University of Oxford
- David G. Saliba
- Kennedy Institute of Rheumatology, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, The University of Oxford
- Elke Kurz
- Kennedy Institute of Rheumatology, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, The University of Oxford
- Audun Kvalvaag
- Kennedy Institute of Rheumatology, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, The University of Oxford
- Lina Chen
- Kennedy Institute of Rheumatology, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, The University of Oxford
- Charity Ganskow
- Kennedy Institute of Rheumatology, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, The University of Oxford
- Huw Colin-York
- Kennedy Institute of Rheumatology, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, The University of Oxford
- Marco Fritzsche
- Kennedy Institute of Rheumatology, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, The University of Oxford
- Yanchun Peng
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, The University of Oxford
- Tao Dong
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, The University of Oxford
- Errin Johnson
- Sir William Dunn School of Pathology, The University of Oxford
- Jesús A. Siller-Farfán
- Sir William Dunn School of Pathology, The University of Oxford
- Omer Dushek
- Sir William Dunn School of Pathology, The University of Oxford
- Erdinc Sezgin
- Science for Life Laboratory, Department of Women’s and Children’s Health, Karolinska Institutet
- Ben Peacock
- NanoFCM, MediCity
- Alice Law
- NanoFCM, MediCity
- Dimitri Aubert
- NanoFCM, MediCity
- Simon Engledow
- Oxford Genomics Centre, Wellcome Centre for Human Genetics, The University of Oxford
- Moustafa Attar
- Kennedy Institute of Rheumatology, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, The University of Oxford
- Svenja Hester
- Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, The University of Oxford
- Roman Fischer
- Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, The University of Oxford
- Francisco Sánchez-Madrid
- Immunology Service, Hospital de la Princesa, Instituto Investigación Sanitaria Princesa, Universidad Autónoma de Madrid
- Michael L. Dustin
- Kennedy Institute of Rheumatology, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, The University of Oxford
- DOI
- https://doi.org/10.1038/s41467-022-31160-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
T cells communicate with antigen-presenting cells (APC) via the signaling crosstalk at the immunological synapse (IS). Here the authors use bead-supported lipid bilayers as synthetic APCs to find that trans-synaptic vesicles produced by T cells in the IS carry specialized cargos distinct from constitutive extracellular vesicles to serve as intercellular messengers.
