Polyethylene Oxide and their Antibacterial Effects Against some Pathogenic Bacteria

Abstract

Background: Poly ethylene oxide is an uncrosslinked, non-ionic linear hydrophilic polymer with a variety of molecular weights. PEO is used to make it, and it offers a number of beneficial qualities for medication delivery and antibacterial uses.. Materials and Methods: The antibacterial activity of polyethylene oxide (PEO) at various concentrations as (80, 40, 20, 10 g/ml) against bacteria in Gram-positive Staphylococcus aureus, Streptococcus pyogenes and Lactobacillus sp. and Gram-negative Enterobacter bugandensis, E. coli , Pseudomonas aeruginosa and Klebsiella pneumonia was investigated in this study. The disk diffusion experiment was used to assess the antimicrobial activity of PEO, as well as each isolate's minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Results: PEO is shown to have strong broad-spectrum antibacterial action against the bacteria studied, that inhibition zone increase their width inversely proportional to PEO concentration, and has even outpaced the efficacy of certain medicines. PEO had MICs ranging from 10 to 20 g/ml, as well as MBCs of 20 to 80 g/ml. In additional studies, PEO was discovered to be strongly associated with the cell of bacteria, which contributed to its inhibitory impact on bacterial invasion and growth. Conclusion: PEO at an appropriate dose effectively decreased bacterial growth. PEO is highly recommended as a cost-effective antibacterial treatment, Specifically, ectopic infection treatment without the risk of bacterial strains becoming antibiotic-resistant.

Keywords

• peo
• mic
• antibacterial activity