Nature Communications (Jan 2020)

Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate

  • Ryosuke Fujiwara,
  • Shuhei Noda,
  • Tsutomu Tanaka,
  • Akihiko Kondo

DOI
https://doi.org/10.1038/s41467-019-14024-1
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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In lignocellulose biomass, microbes prefer consuming glucose over xylose, which affects target compound production. Here, the authors achieve simultaneous utilization of glucose and xylose for target chemical production and cell growth, respectively, and realize high-level production of shikimate pathway derivatives.