Nature Communications (Sep 2021)
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria
- Yibo Xue,
- Jordan L. Morris,
- Kangning Yang,
- Zheng Fu,
- Xianbing Zhu,
- Fraser Johnson,
- Brian Meehan,
- Leora Witkowski,
- Amber Yasmeen,
- Tunde Golenar,
- Mackenzie Coatham,
- Geneviève Morin,
- Anie Monast,
- Virginie Pilon,
- Pierre Olivier Fiset,
- Sungmi Jung,
- Anne V. Gonzalez,
- Sophie Camilleri-Broet,
- Lili Fu,
- Lynne-Marie Postovit,
- Jonathan Spicer,
- Walter H. Gotlieb,
- Marie-Christine Guiot,
- Janusz Rak,
- Morag Park,
- William Lockwood,
- William D. Foulkes,
- Julien Prudent,
- Sidong Huang
Affiliations
- Yibo Xue
- Department of Biochemistry, McGill University
- Jordan L. Morris
- Medical Research Council Mitochondrial Biology Unit, University of Cambridge
- Kangning Yang
- Department of Biochemistry, McGill University
- Zheng Fu
- Department of Biochemistry, McGill University
- Xianbing Zhu
- Department of Biochemistry, McGill University
- Fraser Johnson
- Department of Integrative Oncology, British Columbia Cancer Agency
- Brian Meehan
- Department of Pediatrics, Research Institute of the McGill University Health Centre, Montreal Children’s Hospital, McGill University
- Leora Witkowski
- Department of Human Genetics, McGill University
- Amber Yasmeen
- Division of Gynecologic Oncology, Segal Cancer Center, Jewish General Hospital, McGill University
- Tunde Golenar
- Department of Biochemistry, McGill University
- Mackenzie Coatham
- Department of Oncology, Department of Obstetrics and Gynecology, University of Alberta
- Geneviève Morin
- Department of Biochemistry, McGill University
- Anie Monast
- Department of Biochemistry, McGill University
- Virginie Pilon
- Department of Biochemistry, McGill University
- Pierre Olivier Fiset
- Department of Pathology, McGill University Health Centre
- Sungmi Jung
- Department of Pathology, McGill University Health Centre
- Anne V. Gonzalez
- Department of Medicine, Division of Respiratory Medicine, McGill University Health Centre, Montreal Chest Institute
- Sophie Camilleri-Broet
- Department of Pathology, McGill University Health Centre
- Lili Fu
- Department of Pathology, McGill University Health Centre
- Lynne-Marie Postovit
- Department of Oncology, Department of Obstetrics and Gynecology, University of Alberta
- Jonathan Spicer
- Department of Surgery, McGill University Health Center
- Walter H. Gotlieb
- Division of Gynecologic Oncology, Segal Cancer Center, Jewish General Hospital, McGill University
- Marie-Christine Guiot
- Department of Pathology, Montreal Neurological Hospital/Institute, McGill University Health Centre
- Janusz Rak
- Department of Pediatrics, Research Institute of the McGill University Health Centre, Montreal Children’s Hospital, McGill University
- Morag Park
- Department of Biochemistry, McGill University
- William Lockwood
- Department of Integrative Oncology, British Columbia Cancer Agency
- William D. Foulkes
- Department of Human Genetics, McGill University
- Julien Prudent
- Medical Research Council Mitochondrial Biology Unit, University of Cambridge
- Sidong Huang
- Department of Biochemistry, McGill University
- DOI
- https://doi.org/10.1038/s41467-021-25260-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
SMARCA4/2 loss in ovarian and lung cancers is associated with chemotherapy resistance. Here, the authors show that SMARCA4/2 deficiency in cancer cells reduces the expression of the ER-Ca2+ channel IP3R3 and subsequently calcium transfer to the mitochondria, which inhibits apoptotic cell death.
