Armaghane Danesh Bimonthly Journal (Sep 2019)
The effect of Hydroalcoholic Extract of Nectaroscordum tripedale on Serum Gonadotropin and Sex Hormones Concentration in Diabetic Male Rats
Abstract
Background & aim: Diabetic patients suffer from a variety of reproductive disorders, including loss of libido and disability in fertility. The therapeutic effects of medicinal herbs have been proven in the treatment of very diseases, including infertility. The purpose of this study was to investigate the effect of hydroalcoholic extract of Nectaroscordum tripedale on serum levels of sex hormones in diabetic male rats. Methods: In this experimental study, the animals used were 32 adult male rats which were divided randomly into four groups of eight each. The normal control and diabetic control received distilled water, the sham and diabetic treated groups received 50 mg/kg hydroalcoholic extract of Nectaroscordum tripedale respectively. Diabetes was induced by a single injection of streptozotocin in rats. At the end of the 21st day, the rats were anaesthetized with ether and blood sample was taken from the heart. Following luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone levels were measured. The results were evaluated using one way ANOVA and Tukey test. Results: The results of this study indicated that the hydroalcoholic extract of Nectaroscordum tripedale in diabetic treated group increased serum concentrations of LH, FSH and testosterone compared to the diabetic control group. Also results showed that the hydroalcoholic extract of Nectaroscordum tripedale can increase the average body weight in the treatment group compared to the diabetic control group (P<0.05). Conclusion: It can be concluded that hydroalcoholic extract of the Nectaroscordum tripedale in diabetic treated group significantly increased the activity of pituitary-testicular axis and therefore this plant probably play a role in the treatment of infertility in diabetic patients.
