Nature Communications (Oct 2017)

Structural determinants and functional consequences of protein affinity for membrane rafts

  • Joseph H. Lorent,
  • Blanca Diaz-Rohrer,
  • Xubo Lin,
  • Kevin Spring,
  • Alemayehu A. Gorfe,
  • Kandice R. Levental,
  • Ilya Levental

DOI
https://doi.org/10.1038/s41467-017-01328-3
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

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Lipid rafts are plasma membrane domains that specifically recruit particular proteins. Here, the authors show that the surface area, length and palmitoylation of single-pass transmembrane domains are crucial for raft partitioning and propose a general model to predict protein association with rafts.