Correlation between ABCB1 gene polymorphisms, antiepileptic drug concentrations and treatment response

Abstract

Aim: A possible molecular mechanism of clinically defined multidrug-resistant epilepsy involves drug efflux transporters such as P glycoprotein (P-gp), a member of the ATP-binding cassette subfamily B1 (ABCB1). We have investigated the prevalence of the C3435T, G 2677T/A, and T129C single-nucleotide polymorphisms in the promoter region of MDR1 gene, in Romanian epileptic patients.

Keywords

• mdr1
• antiepileptic drugs
• polymorphism
• non-responders
• p-glycoprotein