The use of a single pass albumin dialysis for the management of liver failure

Azaševac Tijana; Knežević Violeta; Ćelić Dejan; Ljubičić Bojana; Lakić Tanja; Mitić Igor

doi:10.2298/VSP201116027A

Vojnosanitetski Pregled (Jan 2022)

The use of a single pass albumin dialysis for the management of liver failure

Azaševac Tijana,
Knežević Violeta,
Ćelić Dejan,
Ljubičić Bojana,
Lakić Tanja,
Mitić Igor

Affiliations

Azaševac Tijana: University Clinical Center of Vojvodina, Clinic for Nephrology and Clinical Immunology, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia
Knežević Violeta: University Clinical Center of Vojvodina, Clinic for Nephrology and Clinical Immunology, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia
Ćelić Dejan: University Clinical Center of Vojvodina, Clinic for Nephrology and Clinical Immunology, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia
Ljubičić Bojana: ORCiD; University Clinical Center of Vojvodina, Department of Emergency Internal Medicine, Emergency Center, Novi Sad, Serbia
Lakić Tanja: ORCiD; University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia + University Clinical Center of Vojvodina, Department of Pathology and Histology, Novi Sad, Serbia
Mitić Igor: University Clinical Center of Vojvodina, Clinic for Nephrology and Clinical Immunology, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia

DOI: https://doi.org/10.2298/VSP201116027A
Journal volume & issue: Vol. 79, no. 8
pp. 820 – 824

Abstract

Read online

Introduction. A single pass albumin dialysis (SPAD) is a form of extracorporeal liver support system for removing albumin-bound toxins and water-soluble substances that accumulate in liver failure (LF). Case report. We presented three patients hospitalized for LF and treated using the SPAD at the University Clinical Center of Vojvodina, Serbia, from 2018 to 2019. Two of the patients presented with acute LF and one with acute-on-chronic LF. A total of 6 SPAD sessions were performed on each patient, resulting in decreased serum bilirubin and bile acid levels and hepatic encephalopathy grade. On discharge from the hospital, the liver function was improved in all the patients. Conclusion. SPAD removes the hepatotoxic substances without improvement of synthetic liver function. It represents a supportive treatment for LF patients who do not respond to the standard of care, offering a longer time for bridging to organ transplantation or spontaneous recovery of the liver function.

Published in Vojnosanitetski Pregled

ISSN: 0042-8450 (Print); 2406-0720 (Online)
Publisher: Military Health Department, Ministry of Defance, Serbia
Country of publisher: Serbia
LCC subjects: Medicine: Medicine (General)
Website: http://www.doiserbia.nb.rs/journal.aspx?issn=0042-8450

About the journal

Abstract

Keywords