Acquired thrombophilia in pregnancy. Study by questionnaire method in a group of pregnant women

Abstract

Thrombophilias are blood clotting abnormalities that increase the risk of thrombosis. Acquired thrombophilias occur after birth, throughout life and have multiple causes. The most common acquired thrombophilia is antiphospholipid syndrome. Antiphospholipid syndrome is a recognized cause for recurrent miscarriages and premature births. We conducted a study using the questionnaire method, which included 38 questions. thrombophilia in Romania. 99 patients responded to our request to complete the questionnaire, 91 performed tests for the diagnosis of thrombophilia, 85 were diagnosed with thrombophilia (81 diagnosed with inherited thrombophilia, 1 with acquired thrombophilia and 3 with mixed thrombophilia). Women who responded to the online questionnaire reported testing for antiphospholipid antibodies in 16.5% of cases (14 cases) and 28.2% of women (24 cases) reported the determination of lupus anticoagulant, with a positive percentage of 16.7% ( 4 cases). The results of the study may be a starting point for larger batch studies on the correlation between the presence of antiphospholipid antibodies in women with acquired thrombophilia, to more effectively prevent pregnancy complications.

Keywords

• acquired thrombophilia
• lupus anticoagulant
• antiphospholipid antibodies
• pregnancy placental complications