Clomiphene Citrate Challenge Test and Prediction of Outcome in IVF

Abstract

Objective: The aim of this study was to assess the accuracy of ovarian reserve tests, mainly basal and clomiphene stimulated follicle stimulating hormone (FSH) concentrations. Materials and methods: A prospective cohort study was conductedon 120 infertile patients referring to Mirza Koochak Khan Hospital for IVFfrom 2004 to 2006. All the patients underwent clomiphene citrate challenge test (CCCT) and then in vitro fertilization (IVF) was performed. We evaluated predictive power of CCCT to find IVF outcome in women with decreased ovarian reserve in comparison to those who have appropriate ovarian reserve. SPSS 12 was used to analyze the data of this study via student t test, Fisher exact, Chi -square tests and logistic regression analysis. Results: IVF success rate was 11.7% and CCCT sensitivity and specificity were 30.2% and 92.9% while its positive and negative predictive values were 14.9% and 97% respectively. Conclusion:CCCT is a good test in estimating ovarian reserve. Due to its high negative predictive value, lower chance of pregnancy is expected in the cases with abnormal results.

Keywords

• Clomiphene Citrate Challenge test
• Pregnancy
• IVF
• Infertility