Nature Communications (Mar 2019)
A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease
- Cyrielle Caussy,
- Anupriya Tripathi,
- Greg Humphrey,
- Shirin Bassirian,
- Seema Singh,
- Claire Faulkner,
- Ricki Bettencourt,
- Emily Rizo,
- Lisa Richards,
- Zhenjiang Z. Xu,
- Michael R. Downes,
- Ronald M. Evans,
- David A. Brenner,
- Claude B. Sirlin,
- Rob Knight,
- Rohit Loomba
Affiliations
- Cyrielle Caussy
- NAFLD Research Center, Department of Medicine, University of California San Diego
- Anupriya Tripathi
- Center for Microbiome Innovation, University of California San Diego
- Greg Humphrey
- Department of Pediatrics, University of California San Diego
- Shirin Bassirian
- NAFLD Research Center, Department of Medicine, University of California San Diego
- Seema Singh
- NAFLD Research Center, Department of Medicine, University of California San Diego
- Claire Faulkner
- NAFLD Research Center, Department of Medicine, University of California San Diego
- Ricki Bettencourt
- NAFLD Research Center, Department of Medicine, University of California San Diego
- Emily Rizo
- NAFLD Research Center, Department of Medicine, University of California San Diego
- Lisa Richards
- NAFLD Research Center, Department of Medicine, University of California San Diego
- Zhenjiang Z. Xu
- Department of Pediatrics, University of California San Diego
- Michael R. Downes
- Salk Institute for Biological Studies
- Ronald M. Evans
- Salk Institute for Biological Studies
- David A. Brenner
- NAFLD Research Center, Department of Medicine, University of California San Diego
- Claude B. Sirlin
- Liver Imaging Group, Department of Radiology, University of California at San Diego
- Rob Knight
- Center for Microbiome Innovation, University of California San Diego
- Rohit Loomba
- NAFLD Research Center, Department of Medicine, University of California San Diego
- DOI
- https://doi.org/10.1038/s41467-019-09455-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 9
Abstract
Development of cirrhosis in individuals with non-alcoholic fatty liver disease can predict mortality. Here the authors used a unique twin and family cohort to identify a gut microbiome-derived 16sRNA signature that can detect cirrhosis in individuals with non-alcoholic fatty liver disease.
