Nature Communications (May 2020)
The landscape of chromothripsis across adult cancer types
- Natalia Voronina,
- John K. L. Wong,
- Daniel Hübschmann,
- Mario Hlevnjak,
- Sebastian Uhrig,
- Christoph E. Heilig,
- Peter Horak,
- Simon Kreutzfeldt,
- Andreas Mock,
- Albrecht Stenzinger,
- Barbara Hutter,
- Martina Fröhlich,
- Benedikt Brors,
- Arne Jahn,
- Barbara Klink,
- Laura Gieldon,
- Lina Sieverling,
- Lars Feuerbach,
- Priya Chudasama,
- Katja Beck,
- Matthias Kroiss,
- Christoph Heining,
- Lino Möhrmann,
- Andrea Fischer,
- Evelin Schröck,
- Hanno Glimm,
- Marc Zapatka,
- Peter Lichter,
- Stefan Fröhling,
- Aurélie Ernst
Affiliations
- Natalia Voronina
- Group Genome Instability in Tumors, DKFZ
- John K. L. Wong
- Division of Molecular Genetics, DKFZ
- Daniel Hübschmann
- German Cancer Consortium (DKTK)
- Mario Hlevnjak
- Division of Molecular Genetics, DKFZ
- Sebastian Uhrig
- Computational Oncology, Molecular Diagnostics Program, National Center for Tumor Diseases, DKFZ
- Christoph E. Heilig
- German Cancer Consortium (DKTK)
- Peter Horak
- German Cancer Consortium (DKTK)
- Simon Kreutzfeldt
- German Cancer Consortium (DKTK)
- Andreas Mock
- German Cancer Consortium (DKTK)
- Albrecht Stenzinger
- Institute of Pathology, Heidelberg University Hospital
- Barbara Hutter
- Computational Oncology, Molecular Diagnostics Program, National Center for Tumor Diseases, DKFZ
- Martina Fröhlich
- Computational Oncology, Molecular Diagnostics Program, National Center for Tumor Diseases, DKFZ
- Benedikt Brors
- Division of Applied Bioinformatics, DKFZ and NCT Heidelberg
- Arne Jahn
- Institute for Clinical Genetics, Faculty of Medicine Carl Gustav Carus, TU Dresden, ERN-GENTURIS, Hereditary Cancer Syndrome Center Dresden, German Cancer Consortium (DKTK)
- Barbara Klink
- Institute for Clinical Genetics, Faculty of Medicine Carl Gustav Carus, TU Dresden, ERN-GENTURIS, Hereditary Cancer Syndrome Center Dresden, German Cancer Consortium (DKTK)
- Laura Gieldon
- German Cancer Consortium (DKTK)
- Lina Sieverling
- Division of Applied Bioinformatics, DKFZ and NCT Heidelberg
- Lars Feuerbach
- Division of Applied Bioinformatics, DKFZ and NCT Heidelberg
- Priya Chudasama
- Precision Sarcoma Research Group, DKFZ, National Center for Tumor (NCT) Diseases
- Katja Beck
- German Cancer Consortium (DKTK)
- Matthias Kroiss
- Department of Internal Medicine I, Division of Endocrinology and Diabetology, University Hospital Würzburg
- Christoph Heining
- Department of Translational Medical Oncology, NCT Dresden, Dresden, and DKFZ
- Lino Möhrmann
- Department of Translational Medical Oncology, NCT Dresden, Dresden, and DKFZ
- Andrea Fischer
- Institute for Clinical Genetics, Faculty of Medicine Carl Gustav Carus, TU Dresden, ERN-GENTURIS, Hereditary Cancer Syndrome Center Dresden, German Cancer Consortium (DKTK)
- Evelin Schröck
- Institute for Clinical Genetics, Faculty of Medicine Carl Gustav Carus, TU Dresden, ERN-GENTURIS, Hereditary Cancer Syndrome Center Dresden, German Cancer Consortium (DKTK)
- Hanno Glimm
- Department of Translational Medical Oncology, NCT Dresden, Dresden, and DKFZ
- Marc Zapatka
- Division of Molecular Genetics, DKFZ
- Peter Lichter
- Division of Molecular Genetics, DKFZ
- Stefan Fröhling
- German Cancer Consortium (DKTK)
- Aurélie Ernst
- Group Genome Instability in Tumors, DKFZ
- DOI
- https://doi.org/10.1038/s41467-020-16134-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
The shattering of chromosomes is a dramatic early event in tumourigenesis and is termed chromothripsis. Here, the authors examine chromothripsis across 28 tumour types and show that 49% of cancers exhibit features of chromothripsis.
