Regulation of Metabolic Reprogramming by Long Non-Coding RNAs in Cancer

Assunta Sellitto; Giovanni Pecoraro; Giorgio Giurato; Giovanni Nassa; Francesca Rizzo; Pasquale Saggese; Cesar A. Martinez; Claudio Scafoglio; Roberta Tarallo

doi:10.3390/cancers13143485

Cancers (Jul 2021)

Regulation of Metabolic Reprogramming by Long Non-Coding RNAs in Cancer

Assunta Sellitto,
Giovanni Pecoraro,
Giorgio Giurato,
Giovanni Nassa,
Francesca Rizzo,
Pasquale Saggese,
Cesar A. Martinez,
Claudio Scafoglio,
Roberta Tarallo

Affiliations

Assunta Sellitto: Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry ‘Scuola Medica Salernitana’, University of Salerno, 84081 Baronissi, Italy
Giovanni Pecoraro: Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry ‘Scuola Medica Salernitana’, University of Salerno, 84081 Baronissi, Italy
Giorgio Giurato: Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry ‘Scuola Medica Salernitana’, University of Salerno, 84081 Baronissi, Italy
Giovanni Nassa: Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry ‘Scuola Medica Salernitana’, University of Salerno, 84081 Baronissi, Italy
Francesca Rizzo: Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry ‘Scuola Medica Salernitana’, University of Salerno, 84081 Baronissi, Italy
Pasquale Saggese: Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Cesar A. Martinez: Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Claudio Scafoglio: Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Roberta Tarallo: Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry ‘Scuola Medica Salernitana’, University of Salerno, 84081 Baronissi, Italy

DOI: https://doi.org/10.3390/cancers13143485
Journal volume & issue: Vol. 13, no. 14
p. 3485

Abstract

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Metabolic reprogramming is a well described hallmark of cancer. Oncogenic stimuli and the microenvironment shape the metabolic phenotype of cancer cells, causing pathological modifications of carbohydrate, amino acid and lipid metabolism that support the uncontrolled growth and proliferation of cancer cells. Conversely, metabolic alterations in cancer can drive changes in genetic programs affecting cell proliferation and differentiation. In recent years, the role of non-coding RNAs in metabolic reprogramming in cancer has been extensively studied. Here, we review this topic, with a focus on glucose, glutamine, and lipid metabolism and point to some evidence that metabolic alterations occurring in cancer can drive changes in non-coding RNA expression, thus adding an additional level of complexity in the relationship between metabolism and genetic programs in cancer cells.

Published in Cancers

ISSN: 2072-6694 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/cancers/

About the journal

Abstract

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