Phenotypic analysis of catastrophic childhood epilepsy genes

Aliesha Griffin; Colleen Carpenter; Jing Liu; Rosalia Paterno; Brian Grone; Kyla Hamling; Maia Moog; Matthew T. Dinday; Francisco Figueroa; Mana Anvar; Chinwendu Ononuju; Tony Qu; Scott C. Baraban

doi:10.1038/s42003-021-02221-y

Communications Biology (Jun 2021)

Phenotypic analysis of catastrophic childhood epilepsy genes

Aliesha Griffin,
Colleen Carpenter,
Jing Liu,
Rosalia Paterno,
Brian Grone,
Kyla Hamling,
Maia Moog,
Matthew T. Dinday,
Francisco Figueroa,
Mana Anvar,
Chinwendu Ononuju,
Tony Qu,
Scott C. Baraban

Affiliations

Aliesha Griffin: Epilepsy Research Laboratory and Weill Institute for Neuroscience, Department of Neurological Surgery, University of California San Francisco
Colleen Carpenter: Epilepsy Research Laboratory and Weill Institute for Neuroscience, Department of Neurological Surgery, University of California San Francisco
Jing Liu: Epilepsy Research Laboratory and Weill Institute for Neuroscience, Department of Neurological Surgery, University of California San Francisco
Rosalia Paterno: Epilepsy Research Laboratory and Weill Institute for Neuroscience, Department of Neurological Surgery, University of California San Francisco
Brian Grone: Epilepsy Research Laboratory and Weill Institute for Neuroscience, Department of Neurological Surgery, University of California San Francisco
Kyla Hamling: Epilepsy Research Laboratory and Weill Institute for Neuroscience, Department of Neurological Surgery, University of California San Francisco
Maia Moog: Epilepsy Research Laboratory and Weill Institute for Neuroscience, Department of Neurological Surgery, University of California San Francisco
Matthew T. Dinday: Epilepsy Research Laboratory and Weill Institute for Neuroscience, Department of Neurological Surgery, University of California San Francisco
Francisco Figueroa: Epilepsy Research Laboratory and Weill Institute for Neuroscience, Department of Neurological Surgery, University of California San Francisco
Mana Anvar: Epilepsy Research Laboratory and Weill Institute for Neuroscience, Department of Neurological Surgery, University of California San Francisco
Chinwendu Ononuju: Helen Wills Neuroscience Institute, University of California
Tony Qu: Helen Wills Neuroscience Institute, University of California
Scott C. Baraban: Epilepsy Research Laboratory and Weill Institute for Neuroscience, Department of Neurological Surgery, University of California San Francisco

DOI: https://doi.org/10.1038/s42003-021-02221-y
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 13

Abstract

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Griffin et al used CRISPR-Cas9 to generate 40 single-gene mutant zebrafish lines representing childhood epilepsies for which they evaluated larval phenotypes using electrophysiological, behavioral, neuro-anatomical, survival and pharmacological assays. Their study provides a useful resource for the future functional analysis and/or identification of potential anti-epileptic therapies.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal