Epitranscriptome and FMRP Regulated mRNA Translation

Abstract

An important regulatory mechanism affecting mRNA translation involves various covalent modifications of RNA, which establish distinct epitranscriptomic signatures that actively influence various physiological processes. Dendritic translation in mammalian neurons is a potent target for RNA modification-based regulation. In this mini-review, we focus on the effect of potential RNA modifications on the spatiotemporal regulation of the dendritic translation of mRNAs, which are targeted by two important neuronal translational co-regulators, namely TDP-43 and Fragile X Mental Retardation Protein (FMRP).

Keywords

• epitranscriptome
• FMRP
• TDP-43
• RNA methylation
• RNA editing
• dendritic local translation
• neurological diseases