Multi-omic brain and behavioral correlates of cell-free fetal DNA methylation in macaque maternal obesity models

Benjamin I. Laufer; Yu Hasegawa; Zhichao Zhang; Casey E. Hogrefe; Laura A. Del Rosso; Lori Haapanen; Hyeyeon Hwang; Melissa D. Bauman; Judy Van de Water; Ameer Y. Taha; Carolyn M. Slupsky; Mari S. Golub; John P. Capitanio; Catherine A. VandeVoort; Cheryl K. Walker; Janine M. LaSalle

doi:10.1038/s41467-022-33162-7

Nature Communications (Sep 2022)

Multi-omic brain and behavioral correlates of cell-free fetal DNA methylation in macaque maternal obesity models

Benjamin I. Laufer,
Yu Hasegawa,
Zhichao Zhang,
Casey E. Hogrefe,
Laura A. Del Rosso,
Lori Haapanen,
Hyeyeon Hwang,
Melissa D. Bauman,
Judy Van de Water,
Ameer Y. Taha,
Carolyn M. Slupsky,
Mari S. Golub,
John P. Capitanio,
Catherine A. VandeVoort,
Cheryl K. Walker,
Janine M. LaSalle

Affiliations

Benjamin I. Laufer: Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis
Yu Hasegawa: Department of Food Science and Technology, University of California Davis
Zhichao Zhang: Department of Food Science and Technology, University of California Davis
Casey E. Hogrefe: California National Primate Research Center, University of California Davis
Laura A. Del Rosso: California National Primate Research Center, University of California Davis
Lori Haapanen: MIND Institute, School of Medicine, University of California Davis
Hyeyeon Hwang: Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis
Melissa D. Bauman: MIND Institute, School of Medicine, University of California Davis
Judy Van de Water: Perinatal Origins of Disparities Center, University of California Davis
Ameer Y. Taha: Department of Food Science and Technology, University of California Davis
Carolyn M. Slupsky: Department of Food Science and Technology, University of California Davis
Mari S. Golub: California National Primate Research Center, University of California Davis
John P. Capitanio: California National Primate Research Center, University of California Davis
Catherine A. VandeVoort: California National Primate Research Center, University of California Davis
Cheryl K. Walker: MIND Institute, School of Medicine, University of California Davis
Janine M. LaSalle: Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis

DOI: https://doi.org/10.1038/s41467-022-33162-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

Read online

In animal models, maternal obesity is associated with development of neurodevelopmental disorder like phenotypes. Here the authors show in a macaque model that in obese dams, cell-free fetal DNA methylation, inflammatory cytokines, and metabolites correlated with infant brain DNA methylation, lipids, and metabolites.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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