The Efficacy of Platelet-Rich Donor Plasma for the Topical Treatment of Venous Trophic Ulcers

Abstract

The purpose of the study was to evaluate the efficacy of platelet concentrate obtained from donor plasma in the local treatment of venous trophic ulcers. The study included 106 patients (92 women and 14 men) aged from 38 to 79 years with varicose disease of the lower extremities with the sixth stage of chronic venous insufficiency in accordance with the international clinical part of the CEAP classification. The main group included 51 patients who received donor plasma enriched with platelets (106 in 1 μl) in the local treatment. The control group consisted of 55 patients who, in the local treatment, were given only modern dressings in strict accordance with the modern concept of treatment of chronic wounds. The results of the treatment were evaluated after 10 days of medical intervention. The use of the platelet-rich donor plasma in the regional treatment of trophic ulcers of venous etiology stimulates the regeneration processes and initiates the formation of granulation tissue, epithelialization, and angiogenesis. A wide range of local therapeutic effects, stimulating the regeneration, allows reducing the treatment time, improving the quality of life of patients and reducing the cost of treatment.

Keywords

• venous trophic ulcers
• local treatment
• regeneration
• platelet-rich donor plasma