Disorder- and emotional context-specific neurofunctional alterations during inhibitory control in generalized anxiety and major depressive disorder

Congcong Liu; Jing Dai; Yuanshu Chen; Ziyu Qi; Fei Xin; Qian Zhuang; Xinqi Zhou; Feng Zhou; Lizhu Luo; Yulan Huang; Jinyu Wang; Zhili Zou; Huafu Chen; Keith M. Kendrick; Bo Zhou; Xiaolei Xu; Benjamin Becker

NeuroImage: Clinical (Jan 2021)

Disorder- and emotional context-specific neurofunctional alterations during inhibitory control in generalized anxiety and major depressive disorder

Congcong Liu,
Jing Dai,
Yuanshu Chen,
Ziyu Qi,
Fei Xin,
Qian Zhuang,
Xinqi Zhou,
Feng Zhou,
Lizhu Luo,
Yulan Huang,
Jinyu Wang,
Zhili Zou,
Huafu Chen,
Keith M. Kendrick,
Bo Zhou,
Xiaolei Xu,
Benjamin Becker

Affiliations

Congcong Liu: The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for NeuroInformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China
Jing Dai: The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for NeuroInformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China; Chengdu Mental Health Center, Chengdu, Sichuan 610036, China
Yuanshu Chen: The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for NeuroInformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China
Ziyu Qi: The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for NeuroInformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China
Fei Xin: The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for NeuroInformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China
Qian Zhuang: The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for NeuroInformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China
Xinqi Zhou: The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for NeuroInformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China
Feng Zhou: The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for NeuroInformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China
Lizhu Luo: The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for NeuroInformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China; Chengdu Mental Health Center, Chengdu, Sichuan 610036, China
Yulan Huang: Department of Psychosomatic Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610072, China
Jinyu Wang: Department of Psychosomatic Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610072, China
Zhili Zou: Department of Psychosomatic Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610072, China
Huafu Chen: The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for NeuroInformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China
Keith M. Kendrick: The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for NeuroInformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China
Bo Zhou: Department of Psychosomatic Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610072, China; Corresponding authors at: The Center of Psychosomatic Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, No. 32 West Second Section First Ring Road, Chengdu, Sichuan 610072, China (B. Zhou). The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory of Neuroinformation, No. 2006, Xiyuan Ave., West Hi-Tech Zone, Chengdu, Sichuan 611731, China (X. Xu). The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory of Neuroinformation, No. 2006, Xiyuan Ave., West Hi-Tech Zone, Chengdu, Sichuan 611731, China (B. Becker).
Xiaolei Xu: The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for NeuroInformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China; Corresponding authors at: The Center of Psychosomatic Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, No. 32 West Second Section First Ring Road, Chengdu, Sichuan 610072, China (B. Zhou). The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory of Neuroinformation, No. 2006, Xiyuan Ave., West Hi-Tech Zone, Chengdu, Sichuan 611731, China (X. Xu). The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory of Neuroinformation, No. 2006, Xiyuan Ave., West Hi-Tech Zone, Chengdu, Sichuan 611731, China (B. Becker).
Benjamin Becker: The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for NeuroInformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China; Corresponding authors at: The Center of Psychosomatic Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, No. 32 West Second Section First Ring Road, Chengdu, Sichuan 610072, China (B. Zhou). The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory of Neuroinformation, No. 2006, Xiyuan Ave., West Hi-Tech Zone, Chengdu, Sichuan 611731, China (X. Xu). The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory of Neuroinformation, No. 2006, Xiyuan Ave., West Hi-Tech Zone, Chengdu, Sichuan 611731, China (B. Becker).

Journal volume & issue: Vol. 30
p. 102661

Abstract

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Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD) are highly debilitating and often co-morbid disorders. The disorders exhibit partly overlapping dysregulations on the behavioral and neurofunctional level. The determination of disorder-specific behavioral and neurofunctional dysregulations may therefore promote neuro-mechanistic and diagnostic specificity. In order to determine disorder-specific alterations in the domain of emotion-cognition interactions the present study examined emotional context-specific inhibitory control in treatment-naïve MDD (n = 37) and GAD (n = 35) patients and healthy controls (n = 35). On the behavioral level MDD but not GAD exhibited impaired inhibitory control irrespective of emotional context. On the neural level, MDD-specific attenuated recruitment of inferior/medial parietal, posterior frontal, and mid-cingulate regions during inhibitory control were found during the negative context. GAD exhibited a stronger engagement of the left dorsolateral prefrontal cortex relative to MDD. Overall the findings from the present study suggest disorder- and emotional context-specific behavioral and neurofunctional inhibitory control dysregulations in major depression and may point to a depression-specific neuropathological and diagnostic marker.

Published in NeuroImage: Clinical

ISSN: 2213-1582 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: http://www.journals.elsevier.com/neuroimage-clinical/

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