Nature Communications (Feb 2022)
Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites
- Atanu Paul,
- Stefano Annunziato,
- Bo Lu,
- Tianliang Sun,
- Olivera Evrova,
- Lara Planas-Paz,
- Vanessa Orsini,
- Luigi M. Terracciano,
- Olga Charlat,
- Zinger Yang Loureiro,
- Lei Ji,
- Raffaella Zamponi,
- Frederic Sigoillot,
- Hong Lei,
- Alicia Lindeman,
- Carsten Russ,
- John S. Reece-Hoyes,
- Thomas B. Nicholson,
- Jan S. Tchorz,
- Feng Cong
Affiliations
- Atanu Paul
- Novartis Institutes for BioMedical Research, Novartis Pharma AG
- Stefano Annunziato
- Novartis Institutes for BioMedical Research, Novartis Pharma AG
- Bo Lu
- Novartis Institutes for BioMedical Research, Novartis Pharma AG
- Tianliang Sun
- Novartis Institutes for BioMedical Research, Novartis Pharma AG
- Olivera Evrova
- Novartis Institutes for BioMedical Research, Novartis Pharma AG
- Lara Planas-Paz
- Novartis Institutes for BioMedical Research, Novartis Pharma AG
- Vanessa Orsini
- Novartis Institutes for BioMedical Research, Novartis Pharma AG
- Luigi M. Terracciano
- Department of Biomedical Sciences, Humanitas University
- Olga Charlat
- Novartis Institutes for BioMedical Research, Novartis Pharma AG
- Zinger Yang Loureiro
- Novartis Institutes for BioMedical Research, Novartis Pharma AG
- Lei Ji
- Novartis Institutes for BioMedical Research, Novartis Pharma AG
- Raffaella Zamponi
- Novartis Institutes for BioMedical Research, Novartis Pharma AG
- Frederic Sigoillot
- Novartis Institutes for BioMedical Research, Novartis Pharma AG
- Hong Lei
- Novartis Institutes for BioMedical Research, Novartis Pharma AG
- Alicia Lindeman
- Novartis Institutes for BioMedical Research, Novartis Pharma AG
- Carsten Russ
- Novartis Institutes for BioMedical Research, Novartis Pharma AG
- John S. Reece-Hoyes
- Novartis Institutes for BioMedical Research, Novartis Pharma AG
- Thomas B. Nicholson
- Novartis Institutes for BioMedical Research, Novartis Pharma AG
- Jan S. Tchorz
- Novartis Institutes for BioMedical Research, Novartis Pharma AG
- Feng Cong
- Novartis Institutes for BioMedical Research, Novartis Pharma AG
- DOI
- https://doi.org/10.1038/s41467-022-28567-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
How cell-cell contact is sensed by Hippo pathway is poorly understood. Here, the authors show that KIRREL1 functions as a feedback regulator of the mammalian Hippo pathway by sensing cell-cell interaction and recruiting SAV1 to cell-cell contacts.
