BMC Cancer (Mar 2021)

Comparison of clinicopathological features and long-term prognosis between mixed predominantly differentiated-type and pure differentiated-type early gastric cancer

  • Yutaka Okagawa,
  • Tetsuya Sumiyoshi,
  • Hitoshi Kondo,
  • Yusuke Tomita,
  • Takeshi Uozumi,
  • Reiichi Iida,
  • Hiroya Sakano,
  • Kaho Tokuchi,
  • Takashi Jin,
  • Masahiro Yoshida,
  • Akira Sakurada,
  • Ryoji Fujii,
  • Takeyoshi Minagawa,
  • Kohtaro Morita,
  • Kei Yane,
  • Hideyuki Ihara,
  • Michiaki Hirayama,
  • Yumiko Oyamada,
  • Shunichi Okushiba

DOI
https://doi.org/10.1186/s12885-021-07962-x
Journal volume & issue
Vol. 21, no. 1
pp. 1 – 9

Abstract

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Abstract Background Recent studies have shown that mixed predominantly differentiated-type (MD) early gastric cancer (EGC) might have more malignant potential than pure differentiated-type (PD) EGC. However, no study has analyzed all differentiated-type EGC cases treated endoscopically and surgically. This study aimed to compare the differences in clinicopathological features and long-term prognosis between MD- and PD-EGC. Methods We evaluated all patients with differentiated-type EGCs who were treated endoscopically and surgically in our hospital between January 2010 and October 2014. The clinicopathological features and long-term prognosis of MD-EGC were compared with those of PD-EGC. Results A total of 459 patients with 459 lesions were evaluated in this study; of them, 409 (89.1%) and 50 (10.9%) were classified into the PD and MD groups, respectively. Submucosal invasion was found in 96 (23.5%) patients of the PD group and in 33 (66.0%) patients of the MD group (p < 0.01). The rates of positive lymphatic and vascular invasion and ulceration were significantly higher in the MD group than in the PD group (p < 0.01). The proportion of patients with lymph node metastasis was also significantly higher in the MD group than in the PD group (5 (10%) vs 6 (1.5%), p < 0.01). The 5-year overall and EGC-specific survival rates in the PD group were 88.3 and 99.5%, respectively, while they were 94.0 and 98.0% in the MD group, respectively. Conclusions MD-EGC has more malignant potential than PD-EGC. However, the long-term prognosis of MD-EGC is good and is not significantly different from that of PD-EGC when treated appropriately.

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