RUDN Journal of Medicine (Dec 2013)

Combined toxicity of Na 2EDTA and D 2O

  • T N Burdeinaya,
  • O Y Zrelov,
  • T V Maksimova,
  • M A Morozova,
  • G I Mtei,
  • E V Uspenskaya,
  • T V Pleteneva,
  • A V Syroeshkin

Journal volume & issue
Vol. 0, no. 2
pp. 5 – 9

Abstract

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Physicochemical and biopharmaceutical analysis of excipients doesn’t allow to characterize them as inert components of drug products. Excipients are known to exhibit their own biological activity as well as influence the activity of API and other components of the formulation (antioxidants, stabilizers, fillers, etc.). Combined biological activity of stabilizer/antioxidant — disodium ethylenediaminetetraacetate (Na 2EDTA) — and water with different ratios of hydrogen isotopes (D / H) was studied on biological models of Spirotox. It was found that with the growth of deuterium/protium ratio in water the toxicity of Na 2EDTA increased.

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