Nutrients (Sep 2022)
Vitamin D3 Supplementation in Overweight/Obese Pregnant Women: No Effects on the Maternal or Fetal Lipid Profile and Body Fat Distribution—A Secondary Analysis of the Multicentric, Randomized, Controlled Vitamin D and Lifestyle for Gestational Diabetes Prevention Trial (DALI)
- Jürgen Harreiter,
- Lilian C. Mendoza,
- David Simmons,
- Gernot Desoye,
- Roland Devlieger,
- Sander Galjaard,
- Peter Damm,
- Elisabeth R. Mathiesen,
- Dorte M. Jensen,
- Lise Lotte T. Andersen,
- Fidelma Dunne,
- Annunziata Lapolla,
- Maria G. Dalfra,
- Alessandra Bertolotto,
- Ewa Wender-Ozegowska,
- Agnieszka Zawiejska,
- David Hill,
- Judith G. M. Jelsma,
- Frank J. Snoek,
- Christof Worda,
- Dagmar Bancher-Todesca,
- Mireille N. M. van Poppel,
- Rosa Corcoy,
- Alexandra Kautzky-Willer,
- on behalf of the DALI Core Investigator Group
Affiliations
- Jürgen Harreiter
- Gender Medicine Unit, Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, 1090 Vienna, Austria
- Lilian C. Mendoza
- Institut d’Investigació Biomèdica Sant Pau (IIB SANT PAU), 08025 Barcelona, Spain
- David Simmons
- Macarthur Clinical School, Western Sydney University, Sydney 2560, Australia
- Gernot Desoye
- Department of Obstetrics and Gynecology, Medical University of Graz, 8036 Graz, Austria
- Roland Devlieger
- Department of Development and Regeneration, KU Leuven, University Leuven, 3000 Leuven, Belgium
- Sander Galjaard
- Department of Development and Regeneration, KU Leuven, University Leuven, 3000 Leuven, Belgium
- Peter Damm
- Center for Pregnant Women with Diabetes, Departments of Endocrinology and Obstetrics, Rigshospitalet, 2100 Copenhagen, Denmark
- Elisabeth R. Mathiesen
- Center for Pregnant Women with Diabetes, Departments of Endocrinology and Obstetrics, Rigshospitalet, 2100 Copenhagen, Denmark
- Dorte M. Jensen
- Steno Diabetes Center Odense, Odense University Hospital, 5000 Odense, Denmark
- Lise Lotte T. Andersen
- Department of Gynaecology and Obstetrics, Odense University Hospital, 5000 Odense, Denmark
- Fidelma Dunne
- Clinical Research Facility (CRF) and National University of Ireland, H91 TK33 Galway, Ireland
- Annunziata Lapolla
- Department of Medicine, Universita Degli Studi di Padova, 35128 Padova, Italy
- Maria G. Dalfra
- Department of Medicine, Universita Degli Studi di Padova, 35128 Padova, Italy
- Alessandra Bertolotto
- Azienda Ospedaliero-Universitaria Pisana , 56126 Pisa, Italy
- Ewa Wender-Ozegowska
- Department of Reproduction, Medical Faculty I, Poznan University of Medical Sciences, 60-525 Poznan, Poland
- Agnieszka Zawiejska
- Department of Reproduction, Medical Faculty I, Poznan University of Medical Sciences, 60-525 Poznan, Poland
- David Hill
- Lawson Health Research Institute, London, ON N6A 4V2, Canada
- Judith G. M. Jelsma
- Amsterdam UMC, Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, 1081 BT Amsterdam, The Netherlands
- Frank J. Snoek
- Amsterdam UMC, Department of Medical Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, 1007 MB Amsterdam, The Netherlands
- Christof Worda
- Division of Obstetrics and Feto-Maternal Medicine, Department of Obstetrics and Gynecology, Medical University of Vienna, 1090 Vienna, Austria
- Dagmar Bancher-Todesca
- Division of Obstetrics and Feto-Maternal Medicine, Department of Obstetrics and Gynecology, Medical University of Vienna, 1090 Vienna, Austria
- Mireille N. M. van Poppel
- Amsterdam UMC, Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, 1081 BT Amsterdam, The Netherlands
- Rosa Corcoy
- Institut d’Investigació Biomèdica Sant Pau (IIB SANT PAU), 08025 Barcelona, Spain
- Alexandra Kautzky-Willer
- Gender Medicine Unit, Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, 1090 Vienna, Austria
- on behalf of the DALI Core Investigator Group
- DOI
- https://doi.org/10.3390/nu14183781
- Journal volume & issue
-
Vol. 14,
no. 18
p. 3781
Abstract
Vitamin D deficiency is a common finding in overweight/obese pregnant women and is associated with increased risk for adverse pregnancy outcome. Both maternal vitamin D deficiency and maternal obesity contribute to metabolic derangements in pregnancy. We aimed to assess the effects of vitamin D3 supplementation in pregnancy versus placebo on maternal and fetal lipids. Main inclusion criteria were: women 2. Eligible women (n = 154) were randomized to receive vitamin D3 (1600 IU/day) or placebo. Assessments were performed p = 0.012). Vitamin D supplementation in pregnancy increases maternal and cord blood vitamin D significantly resulting in high rates of vitamin D sufficiency. Maternal and cord blood lipid parameters were unaffected by Vitamin D3 supplementation.
Keywords
