synthesis of alumina nanoparticles by thermal decomposition technique using aluminium Schiff base complex and anticancer activity study of synthesized compounds

Abstract

In the peresent work, new aluminium complex from a Schiff base ligand was synthesized and characterized. The Schiff base ligand was derived from the condensation of 5-bromo-2-hydroxybenzaldehyde with 8-aminoquinoline. The synthesized compounds were characterized by elemental analyses, FTIR, and UV-Vis spectroscopy. Alumina nanomaterials were synthesized via thermal decomposition technique using aluminum Schiff base complex. The properties of the obtained nano alumina was studied by FTIR spectra. To investigate the phase formation, powder X-ray diffraction technique was used. Rietveld refinement using powder XRD confirms structure model determined by X-ray diffraction. SEM micrographs were used to investigate the morphology of the obtained material. Anticancer activity of these compounds on MKN-45 and LS174T cancer cell-lines was investigated by MTT assay. All compounds showed anticancer activity and have a very good inhibitory effect on the growth of cells. The cell viability decreased with the increasing concentrations of all compounds. Based on the results, it was found that the proliferation rate of cancer cells decreased after treatment with the compounds in a dose dependent way.

Keywords

• schiff base complexes
• anticancer activity
• alumina nanoparticles
• thermal decomposition
• mtt colorimetric assay