Nature Communications (Nov 2017)
Notch transactivates Rheb to maintain the multipotency of TSC-null cells
- Jun-Hung Cho,
- Bhaumik Patel,
- Santosh Bonala,
- Sasikanth Manne,
- Yan Zhou,
- Surya K. Vadrevu,
- Jalpa Patel,
- Marco Peronaci,
- Shanawaz Ghouse,
- Elizabeth P. Henske,
- Fabrice Roegiers,
- Krinio Giannikou,
- David J. Kwiatkowski,
- Hossein Mansouri,
- Maciej M. Markiewski,
- Brandon White,
- Magdalena Karbowniczek
Affiliations
- Jun-Hung Cho
- Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Science Center
- Bhaumik Patel
- Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Science Center
- Santosh Bonala
- Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Science Center
- Sasikanth Manne
- Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Science Center
- Yan Zhou
- Bioinformatics and Biostatistics Facility, Fox Chase Cancer Center
- Surya K. Vadrevu
- Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Science Center
- Jalpa Patel
- Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Science Center
- Marco Peronaci
- Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Science Center
- Shanawaz Ghouse
- Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Science Center
- Elizabeth P. Henske
- Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Fabrice Roegiers
- Fox Chase Cancer Center
- Krinio Giannikou
- Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School and Dana Farber Cancer Institute
- David J. Kwiatkowski
- Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School and Dana Farber Cancer Institute
- Hossein Mansouri
- Department of Mathematics and Statistics, Texas Tech University
- Maciej M. Markiewski
- Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Science Center
- Brandon White
- Department of Biological Sciences, San Jose State University
- Magdalena Karbowniczek
- Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Science Center
- DOI
- https://doi.org/10.1038/s41467-017-01845-1
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
Tuberous sclerosis complex (TSC) is a rare genetic condition causing tumours with differentiation abnormalities; however the molecular mechanisms causing these defects are unclear. Here the authors show that Notch cooperates with Rheb to block cell differentiation forming a regulatory loop that could underlie TSC tumorigenesis.
