Фармакокинетика и Фармакодинамика (Apr 2014)
Drug-drug interactions in the new antiepileptic drugs: focus to perampanel and zonisamide
Abstract
In the past 25 years, there has been an exponential introduction of new antiepileptic drugs (AEDs) in clinical practice. As is often the treatment of epilepsy carried throughout of life, as part of the patient assigned to polytherapy with other AEDs, their drug-drug interactions are an important factor in the treatment of epilepsy, which can be a major therapeutic challenge. For new AEDs interaction particularly important because they often can only be assigned to an add-on polytherapy, at least the first prescribing. Main pharmacokinetics interaction associated with the induction or inhibition of hepatic enzymes, while mainly pharmacodynamics interaction may result in synergy against adverse effects, although there are also examples of anticonvulsant synergism. This article describes in detail the pharmacokinetics and pharmacodynamics interaction of new AEDs (zonisamide and perampanel) with other AEDs.
