ROLE OF PAX-5 TRANSCRIPTION FACTOR IN IMMUNOLOGICAL PROCESSES

Abstract

Abstract. The review article concerns various features of PAX-5 (paired box 5) transcription factor, its structure, functions, regulation of activity, involvement into differentiation and activation of B lymphocytes, switching to IgE synthesis, its role in oncogenesis, and a putative role of this factor for development of bronchial asthma.Further insight into specific properties of PAX-5 factor in bronchial asthma may provide a promising approach to studying mechanisms of this disorder. (Med. Immunol., 2011, vol. 13, N 6, pp 569-580)

Keywords

• pax-5
• transcription factors
• b lymphocytes
• bronchial asthma
• ige