Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles

Enqi He; Keimpe Wierda; Rhode van Westen; Jurjen H. Broeke; Ruud F. Toonen; L. Niels Cornelisse; Matthijs Verhage

doi:10.1038/ncomms15915

Nature Communications (Jun 2017)

Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles

Enqi He,
Keimpe Wierda,
Rhode van Westen,
Jurjen H. Broeke,
Ruud F. Toonen,
L. Niels Cornelisse,
Matthijs Verhage

Affiliations

Enqi He: Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit (VU)
Keimpe Wierda: Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit (VU)
Rhode van Westen: Department of Clinical Genetics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU Medical Center
Jurjen H. Broeke: Department of Clinical Genetics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU Medical Center
Ruud F. Toonen: Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit (VU)
L. Niels Cornelisse: Department of Clinical Genetics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU Medical Center
Matthijs Verhage: Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit (VU)

DOI: https://doi.org/10.1038/ncomms15915
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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The molecular mechanism underlying the generation and maintenance of the readily releasable pool composed of primed synaptic vesicles is only partially known. Here the authors show that in mouse primary neurons, Munc13-1 and Munc18-1 stabilize primed synaptic vesicles by preventing NSF-dependent de-priming.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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