Chlamydia pneumoniae in Alzheimer's disease pathology

Lalita Subedi; Lalita Subedi; Bhakta Prasad Gaire; Yosef Koronyo; Maya Koronyo-Hamaoui; Maya Koronyo-Hamaoui; Maya Koronyo-Hamaoui; Timothy R. Crother; Timothy R. Crother; Timothy R. Crother

doi:10.3389/fnins.2024.1393293

Frontiers in Neuroscience (May 2024)

Chlamydia pneumoniae in Alzheimer's disease pathology

Lalita Subedi,
Lalita Subedi,
Bhakta Prasad Gaire,
Yosef Koronyo,
Maya Koronyo-Hamaoui,
Maya Koronyo-Hamaoui,
Maya Koronyo-Hamaoui,
Timothy R. Crother,
Timothy R. Crother,
Timothy R. Crother

Affiliations

Lalita Subedi: Department of Pediatrics, Division of Infectious Diseases and Immunology, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA, United States
Lalita Subedi: Infectious and Immunologic Diseases Research Center (IIDRC), Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States
Bhakta Prasad Gaire: Department of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States
Yosef Koronyo: Department of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States
Maya Koronyo-Hamaoui: Department of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States
Maya Koronyo-Hamaoui: Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States
Maya Koronyo-Hamaoui: Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States
Timothy R. Crother: Department of Pediatrics, Division of Infectious Diseases and Immunology, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA, United States
Timothy R. Crother: Infectious and Immunologic Diseases Research Center (IIDRC), Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States
Timothy R. Crother: Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States

DOI: https://doi.org/10.3389/fnins.2024.1393293
Journal volume & issue: Vol. 18

Abstract

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While recent advances in diagnostics and therapeutics offer promising new approaches for Alzheimer's disease (AD) diagnosis and treatment, there is still an unmet need for an effective remedy, suggesting new avenues of research are required. Besides many plausible etiologies for AD pathogenesis, mounting evidence supports a possible role for microbial infections. Various microbes have been identified in the postmortem brain tissues of human AD patients. Among bacterial pathogens in AD, Chlamydia pneumoniae (Cp) has been well characterized in human AD brains and is a leading candidate for an infectious involvement. However, no definitive studies have been performed proving or disproving Cp's role as a causative or accelerating agent in AD pathology and cognitive decline. In this review, we discuss recent updates for the role of Cp in human AD brains as well as experimental models of AD. Furthermore, based on the current literature, we have compiled a list of potential mechanistic pathways which may connect Cp with AD pathology.

Published in Frontiers in Neuroscience

ISSN: 1662-4548 (Print); 1662-453X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/neuroscience

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