Nature Communications (Jun 2018)
Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice
- I-Ling Lu,
- Chien Chen,
- Chien-Yi Tung,
- Hsin-Hung Chen,
- Jia-Ping Pan,
- Chia-Hsiang Chang,
- Jia-Shing Cheng,
- Yi-An Chen,
- Chun-Hung Wang,
- Chia-Wei Huang,
- Yi-Ning Kang,
- Hsin-Yun Chang,
- Lei-Li Li,
- Kai-Ping Chang,
- Yang-Hsin Shih,
- Chi-Hung Lin,
- Shang-Yeong Kwan,
- Jin-Wu Tsai
Affiliations
- I-Ling Lu
- Institute of Brain Science, National Yang-Ming University
- Chien Chen
- Department of Neurology, Neurological Institute, Taipei Veterans General Hospital
- Chien-Yi Tung
- VYM Genome Research Center of National Yang-Ming University
- Hsin-Hung Chen
- National Yang-Ming University School of Medicine
- Jia-Ping Pan
- VYM Genome Research Center of National Yang-Ming University
- Chia-Hsiang Chang
- Institute of Brain Science, National Yang-Ming University
- Jia-Shing Cheng
- Institute of Brain Science, National Yang-Ming University
- Yi-An Chen
- Institute of Brain Science, National Yang-Ming University
- Chun-Hung Wang
- Institute of Brain Science, National Yang-Ming University
- Chia-Wei Huang
- Institute of Brain Science, National Yang-Ming University
- Yi-Ning Kang
- Institute of Brain Science, National Yang-Ming University
- Hsin-Yun Chang
- Institute of Brain Science, National Yang-Ming University
- Lei-Li Li
- Institute of Brain Science, National Yang-Ming University
- Kai-Ping Chang
- National Yang-Ming University School of Medicine
- Yang-Hsin Shih
- National Yang-Ming University School of Medicine
- Chi-Hung Lin
- VYM Genome Research Center of National Yang-Ming University
- Shang-Yeong Kwan
- Department of Neurology, Neurological Institute, Taipei Veterans General Hospital
- Jin-Wu Tsai
- Institute of Brain Science, National Yang-Ming University
- DOI
- https://doi.org/10.1038/s41467-018-04880-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Cortical malformations have a variety of causes. Here the authors use transposon mutagenesis to insert mutations into neural stem cells in the developing mouse cortex to screen for new candidate genes for cortical malformation, and validate some targets in human brain tissue.
