Nature Communications (Jan 2020)

Targeting the tumor vasculature with engineered cystine-knot miniproteins

  • Bonny Gaby Lui,
  • Nadja Salomon,
  • Joycelyn Wüstehube-Lausch,
  • Matin Daneschdar,
  • Hans-Ulrich Schmoldt,
  • Özlem Türeci,
  • Ugur Sahin

DOI
https://doi.org/10.1038/s41467-019-13948-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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Cystine-knot miniprotein are small, highly stable, disulfide-rich peptides with increasing potential as drugs and tumor imaging agents. Here the authors develop cystine-knot miniproteins targeting the vascular tumor marker EDB, and use them as probes for in vivo tumor vasculature imaging.