Anti-inflammatory, analgesic and antioxidant potential of the stem bark of Spondias mangifera Willd.

Abstract

The anti-inflammatory and analgesic activities of the ethyl acetate (EAFSM) and n-butanol (NBFSM) fractions of the alcoholic extract of S. mangifera bark were evaluated using carrageenan-induced rat paw edema and by the tail-flick method in rats. The radical scavenging activity of the ethanolic extract, aqueous extract and fractions was determined with the DPPH radical scavenging capacity assay. Two fractions of the alcoholic extract, EAFSM and NBFSM, at doses of 75, 150, 300 mg/kg b.w. administered orally, showed a significant reduction in paw volume when compared with the respective control group challenged by carrageenan. Different doses of extract fractions also showed a significant prolongation of the tail-flick latency of the rat (P<0.01). Different concentrations of alcoholic, aqueous extracts and fractions of alcoholic extract showed significant free radical scavenging capacity against DPPH generated free radicals.

Keywords

• Amora
• inflammation
• pain
• herbal remedies
• carrageenan challenge