Oxidation of difluorocarbene and subsequent trifluoromethoxylation

Jiao Yu; Jin-Hong Lin; Donghai Yu; Ruobing Du; Ji-Chang Xiao

doi:10.1038/s41467-019-13359-z

Nature Communications (Nov 2019)

Oxidation of difluorocarbene and subsequent trifluoromethoxylation

Jiao Yu,
Jin-Hong Lin,
Donghai Yu,
Ruobing Du,
Ji-Chang Xiao

Affiliations

Jiao Yu: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Jin-Hong Lin: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Donghai Yu: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Ruobing Du: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Ji-Chang Xiao: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-019-13359-z
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 8

Abstract

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Difluorocarbene is a versatile and efficient intermediate for fluorine incorporation. Here, the authors show that difluorocarbene can be oxidized to carbonyl fluoride and this process is confirmed in 18O-trifluoromethoxylation reactions, by observation of AgOCF3 species and theory.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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