Nature Communications (Jul 2021)
Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival
- Nathaniel D. Anderson,
- Yael Babichev,
- Fabio Fuligni,
- Federico Comitani,
- Mehdi Layeghifard,
- Rosemarie E. Venier,
- Stefan C. Dentro,
- Anant Maheshwari,
- Sheena Guram,
- Claire Wunker,
- J. Drew Thompson,
- Kyoko E. Yuki,
- Huayun Hou,
- Matthew Zatzman,
- Nicholas Light,
- Marcus Q. Bernardini,
- Jay S. Wunder,
- Irene L. Andrulis,
- Peter Ferguson,
- Albiruni R. Abdul Razak,
- Carol J. Swallow,
- James J. Dowling,
- Rima S. Al-Awar,
- Richard Marcellus,
- Marjan Rouzbahman,
- Moritz Gerstung,
- Daniel Durocher,
- Ludmil B. Alexandrov,
- Brendan C. Dickson,
- Rebecca A. Gladdy,
- Adam Shlien
Affiliations
- Nathaniel D. Anderson
- Program in Genetics and Genome Biology, The Hospital for Sick Children
- Yael Babichev
- Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
- Fabio Fuligni
- Department of Pediatric Laboratory Medicine, The Hospital for Sick Children
- Federico Comitani
- Program in Genetics and Genome Biology, The Hospital for Sick Children
- Mehdi Layeghifard
- Program in Genetics and Genome Biology, The Hospital for Sick Children
- Rosemarie E. Venier
- Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
- Stefan C. Dentro
- European Molecular Biology Laboratory, European Bioinformatics Institute
- Anant Maheshwari
- Program in Genetics and Genome Biology, The Hospital for Sick Children
- Sheena Guram
- Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
- Claire Wunker
- Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
- J. Drew Thompson
- Program in Genetics and Genome Biology, The Hospital for Sick Children
- Kyoko E. Yuki
- Program in Genetics and Genome Biology, The Hospital for Sick Children
- Huayun Hou
- Program in Genetics and Genome Biology, The Hospital for Sick Children
- Matthew Zatzman
- Program in Genetics and Genome Biology, The Hospital for Sick Children
- Nicholas Light
- Program in Genetics and Genome Biology, The Hospital for Sick Children
- Marcus Q. Bernardini
- Princess Margaret Cancer Centre, University Health Network
- Jay S. Wunder
- Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
- Irene L. Andrulis
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Peter Ferguson
- Princess Margaret Cancer Centre, University Health Network
- Albiruni R. Abdul Razak
- Princess Margaret Cancer Centre, University Health Network
- Carol J. Swallow
- Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
- James J. Dowling
- Program in Genetics and Genome Biology, The Hospital for Sick Children
- Rima S. Al-Awar
- Drug Discovery Program, Ontario Institute for Cancer Research
- Richard Marcellus
- Drug Discovery Program, Ontario Institute for Cancer Research
- Marjan Rouzbahman
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Moritz Gerstung
- European Molecular Biology Laboratory, European Bioinformatics Institute
- Daniel Durocher
- Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
- Ludmil B. Alexandrov
- Department of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California, San Diego
- Brendan C. Dickson
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Rebecca A. Gladdy
- Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
- Adam Shlien
- Program in Genetics and Genome Biology, The Hospital for Sick Children
- DOI
- https://doi.org/10.1038/s41467-021-24677-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Heterogeneity in leiomyosarcomas (LMS) makes treatment of the disease challenging. Here the authors analyze LMS heterogeneity and molecular LMS subtypes using genomics and transcriptomics, finding origins in distinct lineages and associations with survival, in addition to the early emergence of metastatic clones.
