Isothermal microcalorimetry measures UCP1-mediated thermogenesis in mature brite adipocytes

Muhammad Hamza Bokhari; Carina Halleskog; Alice Åslund; Nathalie Boulet; Eva Casadesús Rendos; Jasper Martin Anton de Jong; Robert Csikasz; Ez-Zoubir Amri; Irina Shabalina; Tore Bengtsson

doi:10.1038/s42003-021-02639-4

Communications Biology (Sep 2021)

Isothermal microcalorimetry measures UCP1-mediated thermogenesis in mature brite adipocytes

Muhammad Hamza Bokhari,
Carina Halleskog,
Alice Åslund,
Nathalie Boulet,
Eva Casadesús Rendos,
Jasper Martin Anton de Jong,
Robert Csikasz,
Ez-Zoubir Amri,
Irina Shabalina,
Tore Bengtsson

Affiliations

Muhammad Hamza Bokhari: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
Carina Halleskog: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
Alice Åslund: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
Nathalie Boulet: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
Eva Casadesús Rendos: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
Jasper Martin Anton de Jong: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
Robert Csikasz: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
Ez-Zoubir Amri: Université cote d’azur, CNRS Inserm IBV
Irina Shabalina: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
Tore Bengtsson: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University

DOI: https://doi.org/10.1038/s42003-021-02639-4
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 11

Abstract

Read online

Bokhari et al. demonstrate mature murine brown and brite adipocytes produce quantifiable heat with β3-AR stimulation. They indicate that the essential component of this mechanism is UCP1 by using adipocytes lacking the protein.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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