Journal of Cardiovascular Development and Disease (Jun 2024)

Beyond Medical Therapy—An Update on Heart Failure Devices

  • Luigi Falco,
  • Fabio Valente,
  • Aldo De Falco,
  • Raffaele Barbato,
  • Luigi Marotta,
  • Davide Soviero,
  • Luigi Mauro Cantiello,
  • Carla Contaldi,
  • Benedetta Brescia,
  • Enrico Coscioni,
  • Giuseppe Pacileo,
  • Daniele Masarone

DOI
https://doi.org/10.3390/jcdd11070187
Journal volume & issue
Vol. 11, no. 7
p. 187

Abstract

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Heart failure (HF) is a complex and progressive disease marked by substantial morbidity and mortality rates, frequent episodes of decompensation, and a reduced quality of life (QoL), with severe financial burden on healthcare systems. In recent years, several large-scale randomized clinical trials (RCTs) have widely expanded the therapeutic armamentarium, underlining additional benefits and the feasibility of rapid titration regimens. This notwithstanding, mortality is not declining, and hospitalizations are constantly increasing. It is widely acknowledged that even with guideline-directed medical therapy (GDMT) on board, HF patients have a prohibitive residual risk, which highlights the need for innovative treatment options. In this scenario, groundbreaking devices targeting valvular, structural, and autonomic abnormalities have become crucial tools in HF management. This has led to a full-fledged translational boost with several novel devices in development. Thus, the aim of this review is to provide an update on both approved and investigated devices.

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