A Study of Neonatal Septicaemia in a Tertiary Care Hospital

Abstract

Neonatal sepsis is one of the most common cause of death among neonates in the developing countries. Neonatal infections are estimated to cause 1.6 million deaths every year all over the world and 40 % of deaths occurring in the developing countries like India. To determine the bacteriological profile and antibiogram in neonatal septicemia cases. 99 different neonates, clinically diagnosed were included. Blood specimens for culture were drawn. Bacteria was identified, antibiogram was determined and ESBL test was done Out of 99 clinically suspected cases, 44 cases were culture positive whereas 55 were culture negative. Gram positive bacteria were the most common isolates (68.18%) followed by gram negative bacteria (31.82%). Among the Gram positive bacteria, MRCONS (50%) was the most common followed by MRSA (%). Among gram negative bacteria, Klebsiella (11.36%) was the most common followed by acinetobacter (9.09%), E.coli and Pseudomonas. 93.18% of the cases were EOS whereas 6.82% cases were LOS.92% of CONS were sensitive to linezolid, 84% to chloramphenicol, and 68% to amikacin. All isolates of Staphylococcus aureus were sensitive to linezolid and chloramphenicol. Most of the Gram negative bacteria were resistant to the most commonly used antibiotics.64.28% of Gram negative bacilli were ESBL producers of which Klebsiella was the commonest (44.44%). The increasing spread of different bacteria differing in resistance patterns demands for evidence based practice in neonatal septicemia.

Keywords

• neonatal septicemia
• blood culture
• esbl producers.