Leukemia Research Reports (Jan 2023)

Real world experience with ropeginterferon alpha-2b (Besremi) in essential thrombocythaemia and polycythaemia vera following exposure to pegylated interferon alfa-2a (Pegasys)

  • Jumoke Okikiolu,
  • Claire Woodley,
  • Llywelyn Cadman-Davies,
  • Jennifer O'Sullivan,
  • Deepti Radia,
  • Natalia Curto Garcia,
  • Patrick Harrington,
  • Shahram Kordasti,
  • Susan Asirvatham,
  • Priya Sriskandarajah,
  • Jamie Saunders,
  • Chandan Saha,
  • Irene Sanchez,
  • Hugues deLavallade,
  • Donal P McLornan,
  • Claire N Harrison

Journal volume & issue
Vol. 19
p. 100360

Abstract

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Despite widespread use of Pegylated forms of Inteferon in the management of Myeloproliferative Neoplasms (MPN), most clinicians have experience predominantly with peginterferon alfa-2a (Pegasys). Third generation pegylated IFNα, ropeginterferon alfa-2b (ropegIFN; Besremi), was recommended by the European Medicine Authority (EMA) for treatment of Polycythaemia Vera (PV) following a Phase III trial (PROUD-PV / CONTINUATION-PV). FDA approval for PV, regardless of treatment history, was subsequently granted in November 2021. We hereby demonstrate the safety and tolerability of ropegIFN in a series of MPN patients at variable doses. It corroborates reports of efficacy of ropegIFN in patients with PV and use in pregnancy.

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