Nature Communications (May 2021)

Catalytic asymmetric Nakamura reaction by gold(I)/chiral N,Nʹ-dioxide-indium(III) or nickel(II) synergistic catalysis

  • Xinyue Hu,
  • Xiaoxue Tang,
  • Xiying Zhang,
  • Lili Lin,
  • Xiaoming Feng

DOI
https://doi.org/10.1038/s41467-021-23105-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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Although enols and enolates addition to unactivated alkynes is used for carbon-carbon bond modification a catalytic asymmetric alkyne with 1,3-dicarbonyl compound has been elusive. Here, the authors achieve this using the synergistic activation of chiral N,N′-dioxide-indium(III) or nickel(II) Lewis acid and achiral gold(I) π-acid.”