Medicina v Kuzbasse (Aug 2018)
FEATURES LOCAL AND SYSTEMIC IMMUNE REGULATION IN CATARACT
Abstract
The question of the inflammatory origin of the eye cataract remains open. To identify associative relationships between the severity of the cataract manifestations, complications after its surgical treatment and levels of proinflammatory and antiinflammatory cytokines in the anterior chamber of the eye and peripheral blood was examined 24 patients with uncomplicated presenile cataract of the eyes. The age of the patients was in the range of 28-55 years. The study group included 14 men and 10 women. The concentration of interleukin 1 (IL-1b) receptor antagonist of interleukin 1 (IL-1Rα), interleukin-4 (IL-4), tumor necrosis factor alpha (TNF-α) and interferon alpha (INF-α) blood in the anterior chamber of the eye were measured by enzyme immunoassay. All patients were subjected to general analysis of blood and studied the concentrations of C-reactive protein (CRP) and circulating immune complexes (CIC) in peripheral blood. The study showed that uncomplicated presenile cataract eye patients 28-55 years is a manifestation of disturbed immune regulation by proinflammatory and antiinflammatory cytokines. Based on violations of this regulation are constitutionally due to increased synthesis of TNF-α, defects in the reception of molecules of the family of IL-1, the imbalance in the synthesis of IL-4 and INF-α. Cataract eyes and postoperative complications is positively associated with markers of systemic inflammatory response, concentrations in peripheral blood CRP, CIC, TNF-α.
