Nature Communications (Sep 2022)

Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis

  • Marie Bobowski-Gerard,
  • Clémence Boulet,
  • Francesco P. Zummo,
  • Julie Dubois-Chevalier,
  • Céline Gheeraert,
  • Mohamed Bou Saleh,
  • Jean-Marc Strub,
  • Amaury Farce,
  • Maheul Ploton,
  • Loïc Guille,
  • Jimmy Vandel,
  • Antonino Bongiovanni,
  • Ninon Very,
  • Eloïse Woitrain,
  • Audrey Deprince,
  • Fanny Lalloyer,
  • Eric Bauge,
  • Lise Ferri,
  • Line-Carolle Ntandja-Wandji,
  • Alexia K. Cotte,
  • Corinne Grangette,
  • Emmanuelle Vallez,
  • Sarah Cianférani,
  • Violeta Raverdy,
  • Robert Caiazzo,
  • Viviane Gnemmi,
  • Emmanuelle Leteurtre,
  • Benoit Pourcet,
  • Réjane Paumelle,
  • Kim Ravnskjaer,
  • Guillaume Lassailly,
  • Joel T. Haas,
  • Philippe Mathurin,
  • François Pattou,
  • Laurent Dubuquoy,
  • Bart Staels,
  • Philippe Lefebvre,
  • Jérôme Eeckhoute

DOI
https://doi.org/10.1038/s41467-022-33063-9
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 20

Abstract

Read online

Myofibroblasts contribute to the development of liver fibrosis. Here, the authors report that the transcription factor Basonuclin 2 (BNC2) integrates fibrogenic signals and drives myofibroblastic transcriptional activation in liver fibrosis.