Reactivity of 17β-hydroxy-17α-substituted androstane derivatives

Abstract

The work concerns the reactivity of 17β-hydroxy-17α-substituted androstanes 1-9. Depending on the nature of the 17α-substituent, the presence of the neighboring 16-oximino group, and the reagent used, these compounds can undergo retroaddition (10-12) and fragmentation-cyclization (14-16) reactions.

Keywords

• androstane derivatives
• retroaddition
• fragmentation
• cyclization reaction