Frontiers in Pharmacology (Mar 2022)

Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance

  • Zhuo-fen Deng,
  • Irina Bakunina,
  • Hua Yu,
  • Jaehong Han,
  • Alexander Dömling,
  • Maria-José U Ferreira,
  • Jian-ye Zhang

DOI
https://doi.org/10.3389/fphar.2022.815603
Journal volume & issue
Vol. 13

Abstract

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Multidrug resistance (MDR) is one of the main impediments in successful chemotherapy in cancer treatment. Overexpression of ATP-binding cassette (ABC) transporter proteins is one of the most important mechanisms of MDR. Natural products have their unique advantages in reversing MDR, among which diterpenoids have attracted great attention of the researchers around the world. This review article summarizes and discusses the research progress on diterpenoids in reversing MDR.

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