Nature Communications (May 2019)
Nucleoporin Nup155 is part of the p53 network in liver cancer
- Kerstin Holzer,
- Alessandro Ori,
- Amy Cooke,
- Daniel Dauch,
- Elisabeth Drucker,
- Philip Riemenschneider,
- Amparo Andres-Pons,
- Amanda L. DiGuilio,
- Marie-Therese Mackmull,
- Jochen Baßler,
- Stephanie Roessler,
- Kai Breuhahn,
- Lars Zender,
- Joseph S. Glavy,
- Frank Dombrowski,
- Ed Hurt,
- Peter Schirmacher,
- Martin Beck,
- Stephan Singer
Affiliations
- Kerstin Holzer
- Institute of Pathology, University Hospital Heidelberg
- Alessandro Ori
- Leibniz-Institute on Aging, Fritz-Lipmann-Institute (FLI)
- Amy Cooke
- European Molecular Biology Laboratory, Directors′ Research Unit
- Daniel Dauch
- Department of Internal Medicine VIII, University Hospital Tuebingen
- Elisabeth Drucker
- Institute of Pathology, University Hospital Heidelberg
- Philip Riemenschneider
- Institute of Pathology, University Medicine Greifswald
- Amparo Andres-Pons
- European Molecular Biology Laboratory, Structural and Computational Biology Unit
- Amanda L. DiGuilio
- Department of Chemistry, Chemical Biology and Biomedical Engineering, Stevens Institute of Technology
- Marie-Therese Mackmull
- European Molecular Biology Laboratory, Structural and Computational Biology Unit
- Jochen Baßler
- Heidelberg University Biochemistry Center
- Stephanie Roessler
- Institute of Pathology, University Hospital Heidelberg
- Kai Breuhahn
- Institute of Pathology, University Hospital Heidelberg
- Lars Zender
- Department of Internal Medicine VIII, University Hospital Tuebingen
- Joseph S. Glavy
- Department of Chemistry, Chemical Biology and Biomedical Engineering, Stevens Institute of Technology
- Frank Dombrowski
- Institute of Pathology, University Medicine Greifswald
- Ed Hurt
- Heidelberg University Biochemistry Center
- Peter Schirmacher
- Institute of Pathology, University Hospital Heidelberg
- Martin Beck
- European Molecular Biology Laboratory, Structural and Computational Biology Unit
- Stephan Singer
- Institute of Pathology, University Hospital Heidelberg
- DOI
- https://doi.org/10.1038/s41467-019-10133-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
The nuclear pore complex (NPC) is known to regulate p53 signaling and this has mainly been linked to peripheral NPC subunits. Here the authors show that Nup155 from the NPC inner ring regulates the p53 pathway by controlling p21 translation while also being a target of p53-mediated repression.
