Nature Communications (Mar 2017)

Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF

  • Xusheng Wang,
  • Haiyan Chen,
  • Ruiyun Tian,
  • Yiling Zhang,
  • Marina S. Drutskaya,
  • Chengmei Wang,
  • Jianfeng Ge,
  • Zhimeng Fan,
  • Deqiang Kong,
  • Xiaoxiao Wang,
  • Ting Cai,
  • Ying Zhou,
  • Jingwen Wang,
  • Jinmei Wang,
  • Shan Wang,
  • Zhihai Qin,
  • Huanhuan Jia,
  • Yue Wu,
  • Jia Liu,
  • Sergei A. Nedospasov,
  • Edward E. Tredget,
  • Mei Lin,
  • Jianjun Liu,
  • Yuyang Jiang,
  • Yaojiong Wu

DOI
https://doi.org/10.1038/ncomms14091
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

Read online

Hair can be regenerated after skin wounding. Here the authors show that inflammatory macrophages produce TNF that activates Wnt signalling in hair follicle stem cells to drive this hair regeneration after wound repair in mice.