A New Sesquilignan Glucoside from Uraria sinensis

Yingda Yang; Zhengxi Hu; Zengwei Luo; Yongbo Xue; Guangmin Yao; Yanyan Wang; Yonghui Zhang

doi:10.3390/molecules19011178

Molecules (Jan 2014)

A New Sesquilignan Glucoside from Uraria sinensis

Yingda Yang,
Zhengxi Hu,
Zengwei Luo,
Yongbo Xue,
Guangmin Yao,
Yanyan Wang,
Yonghui Zhang

Affiliations

Yingda Yang: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Zhengxi Hu: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Zengwei Luo: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Yongbo Xue: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Guangmin Yao: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Yanyan Wang: First College of Clinical Medical Science of China, Three Gorges University & Yichang Central People's Hospital, Yichang 443003, China
Yonghui Zhang: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

DOI: https://doi.org/10.3390/molecules19011178
Journal volume & issue: Vol. 19, no. 1
pp. 1178 – 1188

Abstract

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A new sesquilignan glucoside, urariasinoside A (1), together with eight known compounds, including two lignans, a sesquilignan, a dilignan, and four flavonoid derivatives were isolated from the aerial parts of Uraria sinensis. Their structures were determined on the basis of extensive spectroscopic analyses and comparison with literature data. Compound 1 was evaluated for in vitro cytotoxicity activity against HL-60, SMMC-7721, A549, MCF-7, SW480, and BEAS-2B cell lines.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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