Detection and significance of angiogenic factors and vascular endothelial function in patients with hypertensive retinopathy of pregnancy

Abstract

AIM: To investigate the changes of angiogenic factors and vascular endothelial function in patients with hypertensive retinopathy complicating pregnancy, and to analyze the relationship between the relevant factors and the degree of retinopathy. METHODS: Totally 82 cases of patients with hypertensive retinopathy in pregnancy were selected as the research subjects. According to the Duker-Elder fundus staging criteria, they were divided into stage Ⅰ group(n=42), patients with stage Ⅱ group(n=25)and stage Ⅲ group(n=15), in addition, pregnancy hypertension patients without retinopathy were selected as control group. We compared the levels of angiogenic factors and vascular endothelial function among groups, and analyzed the relationship between the levels of relevant factors and retinopathy. RESULTS:The levels of vascular endothelial growth factor(VEGF), insulin like growth factors(IGF-1)and endothelin(ET)-1 in the observation group were significantly higher than those in the control group(PPPCONCLUSION: There are obvious angiogenic factors disorder and vascular endotheial dysfunction in patients with hypertensive retinopathy of pregnancy, and its level is correlated with the degree of retinopathy.

Keywords

• pregnancy induced hypertension
• retinopathy
• angiogenic factor
• vascular endothelial function
• vascular endothelial function