Cumulative Evidence for Relationships Between 8q24 Variants and Prostate Cancer

Yu Tong; Yu Tong; Tao Yu; Tao Yu; Shiping Li; Shiping Li; Fengyan Zhao; Fengyan Zhao; Junjie Ying; Junjie Ying; Yi Qu; Yi Qu; Dezhi Mu; Dezhi Mu

doi:10.3389/fphys.2018.00915

Frontiers in Physiology (Jul 2018)

Cumulative Evidence for Relationships Between 8q24 Variants and Prostate Cancer

Yu Tong,
Yu Tong,
Tao Yu,
Tao Yu,
Shiping Li,
Shiping Li,
Fengyan Zhao,
Fengyan Zhao,
Junjie Ying,
Junjie Ying,
Yi Qu,
Yi Qu,
Dezhi Mu,
Dezhi Mu

Affiliations

Yu Tong: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
Yu Tong: Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
Tao Yu: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
Tao Yu: Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
Shiping Li: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
Shiping Li: Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
Fengyan Zhao: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
Fengyan Zhao: Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
Junjie Ying: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
Junjie Ying: Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
Yi Qu: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
Yi Qu: Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
Dezhi Mu: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
Dezhi Mu: Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China

DOI: https://doi.org/10.3389/fphys.2018.00915
Journal volume & issue: Vol. 9

Abstract

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Multiple independent cancer susceptibility loci at chromosome 8q24 have been identified by GWAS (Genome-wide association studies). Forty six articles including 60,293 cases and 62,971 controls were collected to conduct a meta-analysis to evaluate the associations between 21 variants in 8q24 and prostate cancer risk. Of the 21 variants located in 8q2\5 were significantly associated with the risk of prostate cancer. In particular, both homozygous AA and heterozygous CA genotypes of rs16901979, as well as the AA and CA genotypes of rs1447295, were associated with the risk of prostate cancer. Our study showed that variants in the 8q24 region are associated with prostate cancer risk in this large-scale research synopsis and meta-analysis. Further studies are needed to explore the role of the 8q24 variants involved in the etiology of prostate cancer.

Published in Frontiers in Physiology

ISSN: 1664-042X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Physiology
Website: https://www.frontiersin.org/journals/physiology

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