Communications Biology (Jun 2022)
Population-scale analysis of common and rare genetic variation associated with hearing loss in adults
- Kavita Praveen,
- Lee Dobbyn,
- Lauren Gurski,
- Ariane H. Ayer,
- Jeffrey Staples,
- Shawn Mishra,
- Yu Bai,
- Alexandra Kaufman,
- Arden Moscati,
- Christian Benner,
- Esteban Chen,
- Siying Chen,
- Alexander Popov,
- Janell Smith,
- GHS-REGN DiscovEHR collaboration,
- Regeneron Genetics Center,
- Decibel-REGN collaboration,
- Olle Melander,
- Marcus B. Jones,
- Jonathan Marchini,
- Suganthi Balasubramanian,
- Brian Zambrowicz,
- Meghan C. Drummond,
- Aris Baras,
- Goncalo R. Abecasis,
- Manuel A. Ferreira,
- Eli A. Stahl,
- Giovanni Coppola
Affiliations
- Kavita Praveen
- Regeneron Genetics Center
- Lee Dobbyn
- Regeneron Genetics Center
- Lauren Gurski
- Regeneron Genetics Center
- Ariane H. Ayer
- Regeneron Genetics Center
- Jeffrey Staples
- Regeneron Genetics Center
- Shawn Mishra
- Regeneron Pharmaceuticals, Inc.
- Yu Bai
- Regeneron Pharmaceuticals, Inc.
- Alexandra Kaufman
- Regeneron Pharmaceuticals, Inc.
- Arden Moscati
- Regeneron Genetics Center
- Christian Benner
- Regeneron Genetics Center
- Esteban Chen
- Regeneron Genetics Center
- Siying Chen
- Regeneron Genetics Center
- Alexander Popov
- Regeneron Genetics Center
- Janell Smith
- Regeneron Pharmaceuticals, Inc.
- GHS-REGN DiscovEHR collaboration
- Regeneron Genetics Center
- Decibel-REGN collaboration
- Olle Melander
- Lund University, Department of Clinical Sciences Malmö
- Marcus B. Jones
- Regeneron Genetics Center
- Jonathan Marchini
- Regeneron Genetics Center
- Suganthi Balasubramanian
- Regeneron Genetics Center
- Brian Zambrowicz
- Regeneron Pharmaceuticals, Inc.
- Meghan C. Drummond
- Regeneron Pharmaceuticals, Inc.
- Aris Baras
- Regeneron Genetics Center
- Goncalo R. Abecasis
- Regeneron Genetics Center
- Manuel A. Ferreira
- Regeneron Genetics Center
- Eli A. Stahl
- Regeneron Genetics Center
- Giovanni Coppola
- Regeneron Genetics Center
- DOI
- https://doi.org/10.1038/s42003-022-03408-7
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 12
Abstract
A GWAS and exome-wide association study meta-analysis identifies 53 loci affecting hearing loss risk from over half a million individuals across five cohorts. Rare variants in Mendelian hearing loss genes contribute to hearing loss risk in adults.
